The author is at the National Instititute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. bkelsall@niaid.nih.gov
Mutations in NOD2, encoding an intracellular bacteria-sensing protein, have been associated recently with Crohn disease. Two studies in mice investigate how these mutations may affect innate immunity to microbes in the intestine and progression of disease.
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