The authors are in Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, 55099 Mainz, Germany. blutz@uni-mainz.de
THC acts as a pain reliever in part by engaging a receptor in peripheral tissues, CB2. But exactly where CB2 is and how it operates has been unclear. A new study shows that cannabinoids, acting through CB2 on skin cells, stimulate the local release of endogenous opioids.
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