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Nature Medicine 11, 252 - 253 (2005)
doi:10.1038/nm0305-252
Multiple sclerosis: trapped in deadly glue
Michael Platten1 & Lawrence Steinman1
- Michael Platten is in the Department of Neurology, Department of General Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
- Lawrence Steinman is in Department of Neurology and Neurological Sciences, Beckman Center for Molecular Medicine and the Interdepartmental Program in Immunology, Stanford University, Stanford, California, USA. e-mail: steinman@stanford.edu
Abstract
Two forms of glial cells have distinct roles in the neuroinflammatory cascade of a mouse model of multiple sclerosis. These cells serve as key targets for therapeutic intervention (pages 328–334 and 335–339).
Virchow coined the term 'glia' in the nineteenth century from the Greek word for 'glue.' Microglia are of hematopoietic origin and possess properties of traditional antigen-presenting cells (APCs)1, 2, 3, 4.
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