Nature Medicine
11, 199 - 205 (2005)
Published online: 16 January 2005; | doi:10.1038/nm1178
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesityMark W Sleeman, Katherine E Wortley, Ka-Man V Lai, Lori C Gowen, Jennifer Kintner, William O Kline, Karen Garcia, Trevor N Stitt, George D Yancopoulos, Stanley J Wiegand
& David J GlassSupplementary Fig. 1 (pdf 61K)
Gene targeting of the SHIP2 locus. Supplementary Fig. 2 (pdf 97K)
Facial and X-ray analysis of SHIP2-/- mice did not reveal any gross abnormality. Supplementary Fig. 3 (pdf 112K)
SHIP2 deletion protects female mice from diet-induced obesity and insulin resistance. Supplementary Fig. 4 (pdf 353K)
Additional analysis of insulin signaling of SHIP2-/- mice, both on regular chow and on a high fat diet.
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