Nature Medicine
11, 214 - 222 (2005)
Published online: 23 January 2005; | doi:10.1038/nm1175
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophyEiki Takimoto, Hunter C Champion, Manxiang Li, Diego Belardi, Shuxun Ren, E Rene Rodriguez, Djahida Bedja, Kathleen L Gabrielson, Yibin Wang
& David A KassSupplementary Fig. 1 (pdf 68K)
Free plasma concentration dose response curve to oral sildenafil in mice. Supplementary Fig. 2 (pdf 154K)
Inhibition of PDE5A by EMD360527 prevents load-induced cardiac hypertrophy, improves cardiac function, and reverses fetal gene expression changes. Supplementary Fig. 3 (pdf 335K)
Adenoviral transfection efficiency in neonatal myocytes. Supplementary Fig. 4 (pdf 64K)
NFAT activation assessed in neonatal myocytes transfected with an adenovirus coupling the NFAT promoter coupled to luciferase. Supplementary Table 1 (pdf 86K)
Effect of sildenafil treatment on serial echocardiographic measurements of left ventricular structure and function in conscious mice. Supplementary Table 2 (pdf 89K)
Effect of sildenafil treatment with and without TAC on in vivo cardiac hemodynamics obtained by pressure-volume analysis. Supplementary Table 3 (pdf 15K)
Hemodynamic analysis of non-transgenic controls (NTG) and transgenics with cardiac-targeted Akt overexpression (AktTG). Supplementary Methods (pdf 16K)
| 
