Provider: Nature Publishing Group Content: application/x-research-info-systems TY - JOUR AU - Kahn, B. B. TI - Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance JO - Cell PY - 1998/// VL - 92 SP - 593 EP - 596 M3 - 10.1016/S0092-8674(00)81408-7 N1 - 10.1016/S0092-8674(00)81408-7 UR - http://dx.doi.org/10.1016/S0092-8674(00)81408-7 ER - TY - JOUR AU - Zimmet, P. AU - Alberti, K. G. AU - Shaw, J. TI - Global and societal implications of the diabetes epidemic JO - Nature PY - 2001/// VL - 414 SP - 782 EP - 787 M3 - 10.1038/414782a N1 - 10.1038/414782a UR - http://dx.doi.org/10.1038/414782a ER - TY - JOUR AU - Kahn, B. B. AU - Flier, J. S. TI - Obesity and insulin resistance JO - J Clin Invest PY - 2000/// VL - 106 SP - 473 EP - 81 ER - TY - JOUR AU - Klover, P. J. AU - Zimmers, T. A. AU - Koniaris, L. G. AU - Mooney, R. A. TI - Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice JO - Diabetes PY - 2003/// VL - 52 SP - 2784 EP - 2789 ER - TY - JOUR AU - Grimble, R. F. TI - Inflammatory status and insulin resistance JO - Curr. Opin. Clin. Nutr. Metab. Care PY - 2002/// VL - 5 SP - 551 EP - 559 M3 - 10.1097/00075197-200209000-00015 N1 - 10.1097/00075197-200209000-00015 UR - http://dx.doi.org/10.1097/00075197-200209000-00015 ER - TY - JOUR AU - Pickup, J. C. AU - Crook, M. A. TI - Is type II diabetes mellitus a disease of the innate immune system? JO - Diabetologia PY - 1998/// VL - 41 SP - 1241 EP - 1248 M3 - 10.1007/s001250051058 N1 - 10.1007/s001250051058 UR - http://dx.doi.org/10.1007/s001250051058 ER - TY - JOUR AU - Pickup, J. C. AU - Mattock, M. B. AU - Chusney, G. D. AU - Burt, D. TI - NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X JO - Diabetologia PY - 1997/// VL - 40 SP - 1286 EP - 1292 M3 - 10.1007/s001250050822 N1 - 10.1007/s001250050822 UR - http://dx.doi.org/10.1007/s001250050822 ER - TY - JOUR AU - Festa, A. AU - D'Agostino, R. AU - Tracy, R. P. AU - Haffner, S. M. TI - Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study JO - Diabetes PY - 2002/// VL - 51 SP - 1131 EP - 1137 ER - TY - JOUR AU - Hotamisligil, G. S. TI - Inflammatory pathways and insulin action JO - Int. J. Obes. Relat. Metab. Disord. PY - 2003/// VL - 27 SP - S53 EP - S55 M3 - 10.1038/sj.ijo.0802502 N1 - 10.1038/sj.ijo.0802502 UR - http://dx.doi.org/10.1038/sj.ijo.0802502 ER - TY - JOUR AU - Barnes, P. J. AU - Karin, M. TI - Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases JO - N. Engl. J. Med. PY - 1997/// VL - 336 SP - 1066 EP - 1071 M3 - 10.1056/NEJM199704103361506 N1 - 10.1056/NEJM199704103361506 UR - http://dx.doi.org/10.1056/NEJM199704103361506 ER - TY - JOUR AU - Chen, L. W. TI - The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion JO - Nat. Med. PY - 2003/// VL - 9 SP - 575 EP - 581 M3 - 10.1038/nm849 N1 - 10.1038/nm849 UR - http://dx.doi.org/10.1038/nm849 ER - TY - JOUR AU - Kim, J. K. TI - Prevention of fat-induced insulin resistance by salicylate JO - J. Clin. Invest. PY - 2001/// VL - 108 SP - 437 EP - 446 M3 - 10.1172/JCI200111559 N1 - 10.1172/JCI200111559 UR - http://dx.doi.org/10.1172/JCI200111559 ER - TY - JOUR AU - Yuan, M. TI - Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta JO - Science PY - 2001/// VL - 293 SP - 1673 EP - 1677 M3 - 10.1126/science.1061620 N1 - 10.1126/science.1061620 UR - http://dx.doi.org/10.1126/science.1061620 ER - TY - JOUR AU - Arena, F. P. AU - Dugowson, C. AU - Saudek, C. D. TI - Salicylate-induced hypoglycemia and ketoacidosis in a nondiabetic adult JO - Arch. Intern. Med. PY - 1978/// VL - 138 SP - 1153 EP - 1154 M3 - 10.1001/archinte.138.7.1153 N1 - 10.1001/archinte.138.7.1153 UR - http://dx.doi.org/10.1001/archinte.138.7.1153 ER - TY - JOUR AU - Karin, M. AU - Yamamoto, Y. AU - Wang, Q. M. TI - The IKK NF-kappa B system: a treasure trove for drug development JO - Nat. Rev. Drug Discov. PY - 2004/// VL - 3 SP - 17 EP - 26 M3 - 10.1038/nrd1279 N1 - 10.1038/nrd1279 UR - http://dx.doi.org/10.1038/nrd1279 ER - TY - JOUR AU - Li, Z. W. TI - The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis JO - J. Exp. Med. PY - 1999/// VL - 189 SP - 1839 EP - 1845 M3 - 10.1084/jem.189.11.1839 N1 - 10.1084/jem.189.11.1839 UR - http://dx.doi.org/10.1084/jem.189.11.1839 ER - TY - JOUR AU - Rohl, M. TI - Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance JO - J. Clin. Invest. PY - 2004/// VL - 113 SP - 474 EP - 481 M3 - 10.1172/JCI200418712 N1 - 10.1172/JCI200418712 UR - http://dx.doi.org/10.1172/JCI200418712 ER - TY - JOUR AU - Maeda, S. TI - IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha JO - Immunity PY - 2003/// VL - 19 SP - 725 EP - 737 M3 - 10.1016/S1074-7613(03)00301-7 N1 - 10.1016/S1074-7613(03)00301-7 UR - http://dx.doi.org/10.1016/S1074-7613(03)00301-7 ER - TY - JOUR AU - Greten, F. R. TI - IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer JO - Cell PY - 2004/// VL - 118 SP - 285 EP - 296 M3 - 10.1016/j.cell.2004.07.013 N1 - 10.1016/j.cell.2004.07.013 UR - http://dx.doi.org/10.1016/j.cell.2004.07.013 ER - TY - JOUR AU - Lovejoy, J. C. TI - The influence of dietary fat on insulin resistance JO - Curr. Diab. Rep. PY - 2002/// VL - 2 SP - 435 EP - 440 ER - TY - JOUR AU - Hevener, A. L. TI - Muscle-specific Pparg deletion causes insulin resistance JO - Nat. Med. PY - 2003/// VL - 9 SP - 1491 EP - 1497 M3 - 10.1038/nm956 N1 - 10.1038/nm956 UR - http://dx.doi.org/10.1038/nm956 ER - TY - JOUR AU - Zhang, Y. TI - Positional cloning of the mouse obese gene and its human homologue JO - Nature PY - 1994/// VL - 372 SP - 425 EP - 432 M3 - 10.1038/372425a0 N1 - 10.1038/372425a0 UR - http://dx.doi.org/10.1038/372425a0 ER - TY - JOUR AU - Koistinen, H. A. AU - Zierath, J. R. TI - Regulation of glucose transport in human skeletal muscle JO - Ann. Med. PY - 2002/// VL - 34 SP - 410 EP - 418 M3 - 10.1080/078538902321012351 N1 - 10.1080/078538902321012351 UR - http://dx.doi.org/10.1080/078538902321012351 ER - TY - JOUR AU - Whiteman, E. L. AU - Cho, H. AU - Birnbaum, M. J. TI - Role of Akt/protein kinase B in metabolism JO - Trends Endocrinol. Metab. PY - 2002/// VL - 13 SP - 444 EP - 451 M3 - 10.1016/S1043-2760(02)00662-8 N1 - 10.1016/S1043-2760(02)00662-8 UR - http://dx.doi.org/10.1016/S1043-2760(02)00662-8 ER - TY - JOUR AU - Li, Q. AU - Van Antwerp, D. AU - Mercurio, F. AU - Lee, K. F. AU - Verma, I. M. TI - Severe liver degeneration in mice lacking the IkappaB kinase 2 gene JO - Science PY - 1999/// VL - 284 SP - 321 EP - 325 M3 - 10.1126/science.284.5412.321 N1 - 10.1126/science.284.5412.321 UR - http://dx.doi.org/10.1126/science.284.5412.321 ER - TY - JOUR AU - Ghosh, S. AU - Karin, M. TI - Missing pieces in the NF-[kappa]B puzzle JO - Cell PY - 2002/// VL - 109 SP - S81 EP - S96 M3 - 10.1016/S0092-8674(02)00703-1 N1 - 10.1016/S0092-8674(02)00703-1 UR - http://dx.doi.org/10.1016/S0092-8674(02)00703-1 ER - TY - JOUR AU - Maeda, S. TI - IKK[beta] is required for prevention of apoptosis mediated by cell-bound but not by circulating TNF[alpha] JO - Immunity PY - 2003/// VL - 19 SP - 725 EP - 737 M3 - 10.1016/S1074-7613(03)00301-7 N1 - 10.1016/S1074-7613(03)00301-7 UR - http://dx.doi.org/10.1016/S1074-7613(03)00301-7 ER - TY - JOUR AU - Virkamaki, A. AU - Yki-Jarvinen, H. TI - Mechanisms of insulin resistance during acute endotoxemia JO - Endocrinology PY - 1994/// VL - 134 SP - 2072 EP - 2078 M3 - 10.1210/en.134.5.2072 N1 - 10.1210/en.134.5.2072 UR - http://dx.doi.org/10.1210/en.134.5.2072 ER - TY - JOUR AU - Sugita, H. TI - Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance JO - Am. J. Physiol. Endocrinol. Metab. PY - 2002/// VL - 282 SP - E386 EP - E394 ER - TY - JOUR AU - Cai, D. TI - Local and systemic insulin resistance due to hepatic activation of IKK-[beta] and NF-kB JO - Nat. Med. PY - 2005/// VL - 11 SP - 183 EP - 190 M3 - 10.1038/nm1166 N1 - 10.1038/nm1166 UR - http://dx.doi.org/10.1038/nm1166 ER - TY - JOUR AU - Cai, D. TI - IKKbeta/NF-kappaB activation causes severe muscle wasting in mice JO - Cell PY - 2004/// VL - 119 SP - 285 EP - 298 M3 - 10.1016/j.cell.2004.09.027 N1 - 10.1016/j.cell.2004.09.027 UR - http://dx.doi.org/10.1016/j.cell.2004.09.027 ER - TY - JOUR AU - Samuel, V. T. TI - Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease JO - J. Biol. Chem. PY - 2004/// VL - 279 SP - 32345 EP - 32353 M3 - 10.1074/jbc.M313478200 N1 - 10.1074/jbc.M313478200 UR - http://dx.doi.org/10.1074/jbc.M313478200 ER - TY - JOUR AU - Petersen, K. F. AU - Dufour, S. AU - Befroy, D. AU - Garcia, R. AU - Shulman, G. I. TI - Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes JO - N. Engl. J. Med. PY - 2004/// VL - 350 SP - 664 EP - 671 M3 - 10.1056/NEJMoa031314 N1 - 10.1056/NEJMoa031314 UR - http://dx.doi.org/10.1056/NEJMoa031314 ER - TY - JOUR AU - Moore, K. J. TI - The role of PPAR-gamma in macrophage differentiation and cholesterol uptake JO - Nat. Med. PY - 2001/// VL - 7 SP - 41 EP - 47 M3 - 10.1038/83328 N1 - 10.1038/83328 UR - http://dx.doi.org/10.1038/83328 ER - TY - JOUR AU - Xu, H. TI - Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance JO - J. Clin. Invest. PY - 2003/// VL - 112 SP - 1821 EP - 1830 M3 - 10.1172/JCI200319451 N1 - 10.1172/JCI200319451 UR - http://dx.doi.org/10.1172/JCI200319451 ER - TY - JOUR AU - Weisberg, S. P. TI - Obesity is associated with macrophage accumulation in adipose tissue JO - J. Clin. Invest. PY - 2003/// VL - 112 SP - 1796 EP - 1808 M3 - 10.1172/JCI200319246 N1 - 10.1172/JCI200319246 UR - http://dx.doi.org/10.1172/JCI200319246 ER - TY - JOUR AU - Miyazaki, Y. AU - Pipek, R. AU - Mandarino, L. J. AU - DeFronzo, R. A. TI - Tumor necrosis factor alpha and insulin resistance in obese type 2 diabetic patients JO - Int. J. Obes. Relat. Metab. Disord. PY - 2003/// VL - 27 SP - 88 EP - 94 M3 - 10.1038/sj.ijo.0802187 N1 - 10.1038/sj.ijo.0802187 UR - http://dx.doi.org/10.1038/sj.ijo.0802187 ER - TY - JOUR AU - Bruun, J. M. AU - Pedersen, S. B. AU - Kristensen, K. AU - Richelsen, B. TI - Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro JO - Mol. Cell. Endocrinol. PY - 2002/// VL - 190 SP - 91 EP - 99 M3 - 10.1016/S0303-7207(02)00007-2 N1 - 10.1016/S0303-7207(02)00007-2 UR - http://dx.doi.org/10.1016/S0303-7207(02)00007-2 ER - TY - JOUR AU - Patti, M. E. TI - Gene expression in humans with diabetes and prediabetes: what have we learned about diabetes pathophysiology? JO - Curr. Opin. Clin. Nutr. Metab. Care PY - 2004/// VL - 7 SP - 383 EP - 390 M3 - 10.1097/01.mco.0000134359.23288.72 N1 - 10.1097/01.mco.0000134359.23288.72 UR - http://dx.doi.org/10.1097/01.mco.0000134359.23288.72 ER - TY - JOUR AU - Li, Q. AU - Verma, I. M. TI - NF-[kappa]B regulation in the immune system JO - Nat. Rev. Immunol. PY - 2002/// VL - 2 SP - 725 EP - 734 M3 - 10.1038/nri910 N1 - 10.1038/nri910 UR - http://dx.doi.org/10.1038/nri910 ER - TY - JOUR AU - Leffert, H. L. AU - Koch, K. S. AU - Moran, T. AU - Williams, M. TI - Liver cells JO - Methods Enzymol. PY - 1979/// VL - 58 SP - 536 EP - 544 ER - TY - JOUR AU - Arkan, M. C. AU - Leonarduzzi, G. AU - Biasi, F. AU - Basaga, H. AU - Poli, G. TI - Physiological amounts of ascorbate potentiate phorbol ester-induced nuclear-binding of AP-1 transcription factor in cells of macrophagic lineage JO - Free Radic. Biol. Med. PY - 2001/// VL - 31 SP - 374 EP - 382 M3 - 10.1016/S0891-5849(01)00601-3 N1 - 10.1016/S0891-5849(01)00601-3 UR - http://dx.doi.org/10.1016/S0891-5849(01)00601-3 ER - TY - JOUR AU - Hu, Y. TI - IKK[alpha] controls formation of the epidermis independently of NF-[kappa]B via a differentiation inducing factor JO - Nature PY - 2001/// VL - 410 SP - 710 EP - 714 M3 - 10.1038/35070605 N1 - 10.1038/35070605 UR - http://dx.doi.org/10.1038/35070605 ER -