Nature Medicine 11, 1284 - 1285 (2005)
doi:10.1038/nm1205-1284
Locating heart failureJeffery D Molkentin
The author is at the Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA. jeff.molkentin@cchmc.org
Local levels of cAMP regulate the precise opening of the ryanodine receptor complex—which releases calcium at the start of a heartbeat. Loss or inhibition of phosphodiesterase 4D enzymatic activity leads to calcium leak, heart failure and arrhythmia.
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