Regulation of lung injury and repair by Toll-like receptors and hyaluronan

Dianhua Jiang, Jiurong Liang, Juan Fan, Shuang Yu, Suping Chen, Yi Luo, Glenn D Prestwich, Marcella M Mascarenhas, Hari G Garg, Deborah A Quinn, Robert J Homer, Daniel R Goldstein, Richard Bucala, Patty J Lee, Ruslan Medzhitov & Paul W Noble

Supplementary Fig. 1 (pdf 72K)
Hyaluronan fragment–induced chemokine expression is TLR2-, TLR4- and MyD88-dependent.

Supplementary Fig. 2 (pdf 68K)
Hyaluronan fragment–induced chemokine expression is independent of TLR1, TLR3, TLR5 and TLR9.

Supplementary Fig. 3 (pdf 52K)
Human hyaluronan fragment–induced chemokine expression is TLR2-, TLR4- and MyD88-dependent.

Supplementary Fig. 4 (pdf 104K)
Specificity of hyaluronan-induced chemokine expression.

Supplementary Fig. 5 (pdf 48K)
Effect of KC on inflammatory responses to bleomycin lung injury.

Supplementary Fig. 6 (pdf 40K)
Impaired KC induction by bleomycin in Tlr2^-/-Tlr4^-/- epithelial cells.

Supplementary Fig. 7 (pdf 48K)
Tlr2^-/-Tlr4^-/- mice are more susceptible to hyperoxia.

Supplementary Fig. 8 (pdf 48K)
Effect of hyaluronan-blocking peptide on survival of mice with bleomycin injury.

Supplementary Methods (pdf 40K)

Top