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Article
Nature Medicine 11, 1197 - 1204 (2005)
Published online: 23 October 2005; | doi:10.1038/nm1313

Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling

Kengo F Kusano, Roberto Pola, Toshinori Murayama, Cynthia Curry, Atsuhiko Kawamoto, Atsushi Iwakura, Satoshi Shintani, Masaaki Ii, Jun Asai, Tengiz Tkebuchava, Tina Thorne, Hideya Takenaka, Ryuichi Aikawa, David Goukassian, Patrick von Samson, Hiromichi Hamada, Young-sup Yoon, Marcy Silver, Elizabeth Eaton, Hong Ma, Lindsay Heyd, Marianne Kearney, William Munger, Jeffery A Porter, Raj Kishore & Douglas W Losordo

Supplementary Fig. 1 (pdf 84K)
Shh receptor Ptc1 is expressed in nucleus and cytoplasm of cardiomyocytes.

Supplementary Fig. 2 (pdf 92K)
Shh receptor Ptc1 is expressed in nucleus and cytoplasm of cardiomyocytes.

Supplementary Fig. 3 (pdf 60K)
Shh upregulates expression of multiple factors in adult fibroblasts.

Supplementary Methods (pdf 128K)


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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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