Nature Medicine 11, 1180 - 1187 (2005)
Published online: 2 October 2005; | doi:10.1038/nm1303
CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infectionJeffrey W Tyner, Osamu Uchida, Naohiro Kajiwara, Edy Y Kim, Anand C Patel, Mary P O'Sullivan, Michael J Walter, Reto A Schwendener, Donald N Cook, Theodore M Danoff
& Michael J Holtzman Supplementary Fig. 1 (pdf 3M)
Time course of viral replication and Ccl5 and Ccr5 expression. Supplementary Fig. 2 (pdf 132K)
Similar T-cell activation in Ccl5-null and wild-type control mice. Supplementary Fig. 3 (pdf 1M)
Decreased survival and increased macrophage apoptosis after influenza virus infection in Ccl5- and Ccr5-null mice. Supplementary Fig. 4 (pdf 3M)
Time course of viral persistence and macrophage accumulation and apoptosis in Ccl5-null mice. Supplementary Fig. 5 (pdf 1M)
Ccr5 induction and Ccl5/Ccr5 protection from apoptosis in mouse macrophages after viral infection. Supplementary Fig. 6 (pdf 488K)
CCL3, CCL4, and CCL5 signaling to ERK/AKT at low ligand levels and CCL5 signaling to Src/MEK/ERK at high ligand levels. Supplementary Fig. 7 (pdf 484K)
Ccl5 protection against virus-induced apoptosis in airway epithelial cells. Supplementary Fig. 8 (pdf 560K)
Scheme for mechanisms of apoptosis during viral infection. Supplementary Methods (pdf 88K)
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