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Nature Medicine 11, 1161 - 1162 (2005)
doi:10.1038/nm1105-1161

TLRs play good cop, bad cop in the lung

Luke A J O'Neill1

  1. The author is in the School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland. e-mail: laoneill@tcd.ie

Toll-like receptors act as mediators of injury or repair in the inflamed lung, and the balance depends on the integrity of a component of the extracellular matrix (pages 1173–1179).

Inflammation, like most biological processes, has a good side and a bad side. Understanding the basis for the bad side has been a major area of research, as dysregulation of the inflammatory process forms the basis of many diseases.

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