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Nature Medicine 11, 1153 - 1154 (2005)
doi:10.1038/nm1105-1153
Diuretic soothes seizures in newborns
Atsuo Fukuda1
- The author is in the Department of Physiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan. e-mail: axfukuda@hama-med.ac.jp
Abstract
Infants with seizures have few treatment options, because anticonvulsants effective in adults rarely work. A widely used diuretic takes advantage of the unique physiology of the developing brain and could lead to a therapy (pages 1205–1213).
Seizures in adults are often treated with anticonvulsant drugs that alter the flux of chloride through the neuron. But in children, there are no reliable anticonvulsant drugs, in part because the concentrations of chloride in children's neurons is different than in adults.
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