Nature Medicine 11, 1156 - 1159 (2005)
doi:10.1038/nm1105-1156
Cancer: the matrix is now in controlPaolo M Comoglio
& Livio Trusolino
The authors are in the Division of Molecular Oncology, IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo (Torino), Italy. paolo.comoglio@ircc.it or livio.trusolino@ircc.it
The extracellular matrix is traditionally regarded as a facilitator of tumor progression, providing an environment in which cells can grow and metastasize. Three new studies take the matrix out of this context and suggest that the microenvironment can not only subsidize, but also initiate, the oncogenic conversion of epithelial cells.
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