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Letter
Nature Medicine 11, 1104 - 1108 (2005)
Published online: 11 September 2005; | doi:10.1038/nm1299

Cdk5-dependent regulation of glucose-stimulated insulin secretion

Fan-Yan Wei, Kazuaki Nagashima, Toshio Ohshima, Yasunori Saheki, Yun-Fei Lu, Masayuki Matsushita, Yuichiro Yamada, Katsuhiko Mikoshiba, Yutaka Seino, Hideki Matsui & Kazuhito Tomizawa

Supplementary Fig. 1 (pdf 156K)
Suppression of Cdk5 expression level by siRNA enhanced insulin secretion in MIN6 cells.

Supplementary Fig. 2 (pdf 188K)
Reduced phosphorylation level of Ser783 of alphalc in the brain and islets of p35-deficient mice.

Supplementary Fig. 3 (pdf 1M)
Immunostaining of islets in wild-type and p35-knockout mice.

Supplementary Fig. 4 (pdf 2M)
Islet mass of wild-type and p35-deficient mice.

Supplementary Methods (pdf 76K)


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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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