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Article
Nature Medicine 11, 1088 - 1095 (2005)
Published online: 11 September 2005; | doi:10.1038/nm1298

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

Masahiro Waza, Hiroaki Adachi, Masahisa Katsuno, Makoto Minamiyama, Chen Sang, Fumiaki Tanaka, Akira Inukai, Manabu Doyu & Gen Sobue

Supplementary Fig. 1 (pdf 156K)
Effect of 17-AAG on th expression of mutant AR under the inhibition of the heat-shock response.

Supplementary Fig. 2 (pdf 364K)
The hematological examination of male AR-97Q mice treated with 17-AAG.

Supplementary Fig. 3 (pdf 808K)
Quantification of large aggregated and soluble monomeric mutant AR protein by filter-trap assay.

Supplementary Fig. 4 (pdf 592K)
Effect of 17-AAG on the expression of each chaperone in male AR-97Q mice.

Supplementary Methods (pdf 152K)


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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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