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Article
Nature Medicine 11, 1096 - 1103 (2005)
Published online: 11 September 2005; | doi:10.1038/nm1295

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2−dependent mechanisms

Rei Shibata, Kaori Sato, David R Pimentel, Yukihiro Takemura, Shinji Kihara, Koji Ohashi, Tohru Funahashi, Noriyuki Ouchi & Kenneth Walsh

Supplementary Fig. 1 (pdf 156K)
Adiponectin deficiency does not affect capillary vessel density.

Supplementary Fig. 2 (pdf 204K)
Adiponectin deficiency does not affect IL-1beta or IL-6 levels.

Supplementary Fig. 3 (pdf 136K)
The COX-2 inhibitor NS398 does not affect the adiponectin-mediated inhibition of cultured cardiac myocyte and fibroblast apoptosis.

Supplementary Fig. 4 (pdf 276K)
Adiponectin suppresses LPS-induced TNFalpha secretion from cardiac fibroblasts through a COX-2-dependent pathway.

Supplementary Fig. 5 (pdf 564K)
Adiponectin effects in cultured adult rat myocyte cultures.


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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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