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Nature Medicine 11, 1047 - 1048 (2005)
doi:10.1038/nm1005-1047
HIF, a missing link between metabolism and cancer
Miguel A Esteban1 & Patrick H Maxwell1
- The authors are in the Renal Section, Hammersmith Hospital, Imperial College London, London W12 0NN, UK. e-mail: p.maxwell@imperial.ac.uk
Abstract
Mutations in metabolic enzymes lead to changes in stability of HIF, highlighting the connection between metabolism and cancer.
In 2002, a rare autosomal dominant syndrome characterized by tumors of the skin, uterus and kidney was traced to mutations in the gene encoding fumarate hydratase, an enzyme of the tricarboxylic acid cycle1. Intriguingly, several studies had shown that other familial tumor syndromes are associated with mutations in the gene encoding another enzyme of the tricarboxylic acid cycle, succinate dehydrogenase2.
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