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Nature Medicine 11, 1088 - 1095 (2005)
Published online: 11 September 2005; | doi:10.1038/nm1298

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

Masahiro Waza, Hiroaki Adachi, Masahisa Katsuno, Makoto Minamiyama, Chen Sang, Fumiaki Tanaka, Akira Inukai, Manabu Doyu & Gen Sobue

 
Figure 1 thumbnailFigure 1.
Effect of 17-AAG on the AR or chaperones in cultured-cell models.

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Immunoprecipitation of wild-type and mutant AR in cultured-cell models.

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Figure 3 thumbnailFigure 3.
Pharmacological change in the AR-Hsp90 complex, and the correlation to proteasomal degradation.

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Effects of 17-AAG on behavioral and visible phenotypes in male AR-97Q mice.

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Figure 5 thumbnailFigure 5.
Effects of 17-AAG on the histopathology of male AR-97Q mice.

Full FigureFull Figure and legend (49K)		 Figure 6 thumbnailFigure 6.
Effects of 17-AAG on AR expression in male AR-24Q or 97Q mice.

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