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Figure 5

Nature Medicine 11, 1088 - 1095 (2005)
Published online: 11 September 2005; | doi:10.1038/nm1298

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

Masahiro Waza, Hiroaki Adachi, Masahisa Katsuno, Makoto Minamiyama, Chen Sang, Fumiaki Tanaka, Akira Inukai, Manabu Doyu & Gen Sobue

 
Fig 5 full size
Figure 5. Effects of 17-AAG on the histopathology of male AR-97Q mice.
(a,b) Immunohistochemical staining with 1C2-specific antibody showed marked differences in diffuse nuclear staining and nuclear inclusions between Tg-0 and Tg-25 mice in the spinal anterior horn and skeletal muscle, respectively. (c) Immunohistochemical staining with GFAP-specific antibody also showed an obvious reduction of reactive astrogliosis in the spinal anterior horn of mice treated with 17-AAG. (d) Hematoxylin and eosin staining of the muscle in Tg-0 mice showed obvious grouped atrophy and small angulated fibers, which were not seen in Tg-25 mice. (e) There was a significant reduction in 1C2-positive cell staining in the spinal cord (P < 0.01) and skeletal muscle (P < 0.05) in Tg-25 as compared to Tg-0 mice. Values are expressed as mean plusminus s.e.m. (n = 6). * P < 0.05, ** P < 0.01.

 
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