 | Figure 4
Nature Medicine 11, 1088 - 1095 (2005)
Published online: 11 September 2005; | doi:10.1038/nm1298
17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degenerationMasahiro Waza, Hiroaki Adachi, Masahisa Katsuno, Makoto Minamiyama, Chen Sang, Fumiaki Tanaka, Akira Inukai, Manabu Doyu
& Gen Sobue | | | | Figure 4. Effects of 17-AAG on behavioral and visible phenotypes in male AR-97Q mice.
(a) Rotarod task (n = 27), (b) cage activity (n = 18), (c) body weight (n = 27) and (d) survival rate (n = 27) of Tg-0, Tg-2.5 and Tg-25 mice. All parameters were significantly different between the Tg-0 and Tg-25 (P < 0.005 for all parameters). A Kaplan-Meier plot shows the prolonged survival of Tg-2.5 and Tg-25 compared with Tg-0, which had all died by 25 weeks of age (P = 0.004, P < 0.001, respectively). (e) Representative photographs of a 16-week-old Tg-0 (left) shows an obvious difference in size, and illustrates muscular atrophy and kyphosis compared with an age-matched Tg-25 (right). (f) Footprints of representative 16-week-old Tg-0, Tg-2.5 and Tg-25 mice. Front paws are indicated in red and hind paws in blue. (g) The length of steps was measured in 16-week-old Tg-0, Tg-2.5 and Tg-25 mice. Each column shows an average of steps of the hind paw. Values are expressed as means  s.e.m. (n = 6). *
P < 0.025, **
P < 0.005.
|
| | | |  |
|
