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Nature Medicine 11, 1096 - 1103 (2005)
Published online: 11 September 2005; | doi:10.1038/nm1295

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2−dependent mechanisms

Rei Shibata, Kaori Sato, David R Pimentel, Yukihiro Takemura, Shinji Kihara, Koji Ohashi, Tohru Funahashi, Noriyuki Ouchi & Kenneth Walsh

 
Figure 1 thumbnailFigure 1.
Increased myocardial infarction, myocardial apoptosis and TNF-alpha expression in APN-KO mice subjected to ischemia-reperfusion injury.

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 Figure 2 thumbnailFigure 2.
Adenovirus-mediated expression of adiponectin diminishes infarct size, apoptosis and TNF-alpha production after ischemia-reperfusion in wild-type (WT) and APN-KO mice.

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Figure 3 thumbnailFigure 3.
AMPK-dependent inhibition of cardiac myocyte and fibroblast apoptosis by adiponectin.

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 Figure 4 thumbnailFigure 4.
Adiponectin suppresses LPS-induced secretion of TNF-alpha from neonatal myocytes through a COX-2−dependent pathway.

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Figure 5 thumbnailFigure 5.
Inhibition of COX-2 partially prevents the protective actions of adiponectin on myocardial infarct size after ischemia-reperfusion injury in wild-type (WT) and APN-KO mice.

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