Nature Medicine 11, 1052 - 1053 (2005)
doi:10.1038/nm1005-1052
Targeting toxic proteins for turnoverAlbert R La Spada1
& Patrick Weydt21
Albert R. La Spada is in the Departments of Laboratory Medicine, Medicine and Neurology, and The Center for Neurogenetics & Neurotherapeutics, University of Washington, Seattle, Washington 98195, USA. laspada@u.washington.edu
2
Patrick Weydt is in the Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA. Results now emerge from a preclinical trial of a heat-shock protein inhibitor in a mouse model of neurodegenerative disease. The data indicate that targeting a misfolded protein for degradation may be a useful therapeutic strategy (pages 1088−1095).
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