Nature Medicine
11, 95 - 101 (2004)
Published online: 26 December 2004; | doi:10.1038/nm1169
Tissue-print and print-phoresis as platform technologies for the molecular analysis of human surgical specimens: mapping tumor invasion of the prostate capsuleSandra M Gaston, Marc A Soares, M Minhaj Siddiqui, Dang Vu, Jung M Lee, Dana L Goldner, Mark J Brice, Jennifer C Shih, Melissa P Upton, George Perides, Jovanna Baptista, Philip T Lavin, B Nicolas Bloch, Elizabeth M Genega, Mark A Rubin
& Robert E LenkinskiSupplementary Fig. 1 (pdf 32K)
Reverse transcriptase PCR (rtPCR) of PSA mRNA from an interior prostate tissue print. Supplementary Fig. 2 (pdf 194K)
Quantitative rtPCR profiles of  2M, PSA and AMACR transcripts in RNA extracted from tissue prints of 16 prostate needle
biopsies. Supplementary Fig. 3 (pdf 53K)
Detection of protein markers by print-phoresis. Supplementary Fig. 4 (pdf 125K)
Flow chart of spatial-molecular profiling of tumor-associated proteins with tissue print and print-phoresis technologies. Supplementary Fig. 5 (pdf 123K)
Print-phoresis profiling of collagen fragments colocalized with a high grade tumor focus within the parenchyma
of the prostate gland. Supplementary Fig. 6 (pdf 228K)
Print-phoresis profiling of collagen fragments on the external surface of the prostate capsule. Supplementary Fig. 7 (pdf 102K)
Histopathologically evident tumor invasion of the prostate capsule. Supplementary Table 1 (pdf 23K)
Tissue print marker-marker associations on the external surface of radical prostatectomy
specimens: 78 sextants Supplementary Methods (pdf 30K)
|
