Nature Medicine
11, 77 - 84 (2004)
Published online: 26 December 2004; | doi:10.1038/nm1161
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cellsAngela Nebbioso, Nicole Clarke, Emilie Voltz, Emmanuelle Germain, Concetta Ambrosino, Paola Bontempo, Rosana Alvarez, Ettore M Schiavone, Felicetto Ferrara, Francesco Bresciani, Alessandro Weisz, Angel R de Lera, Hinrich Gronemeyer
& Lucia AltucciSupplementary Fig. 1 (pdf 33K)
Three HDAC inhibitors induce TRAIL mRNA and protein expression in different myeloid cell lines. Supplementary Fig. 2 (pdf 83K)
Permanent RNA interference to reveal the specific roles of TRAIL and p21, kinetics of differentiation and apoptosis markers, and TRAIL
promoter analysis by ChIP assays. Supplementary Fig. 3 (pdf 53K)
MS275-induced TRAIL expression precedes differentiation and is responsible for antitumor activity of MS275 in vivo. Supplementary Fig. 4 (pdf 28K)
Effect of MS275 exposure on TRAIL mRNA and protein expression in AML patients' blasts and normal
CD34+ progenitors.
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