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| Editorial |  Top |
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Statistically significant p1
doi:10.1038/nm0105-1
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| News | Top |
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New patent rules drive Indian drug firms to research p3
K.S. Jayaraman
doi:10.1038/nm0105-3a
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US AIDS chief altered report on nevirapine safety risks p3
Emily Singer
doi:10.1038/nm0105-3b
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Pandemic fears hatch new methods in flu vaccine industry p4
Emily Singer
doi:10.1038/nm0105-4a
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Allegations fly over fate of UK medical research institute p4
Xavier Bosch
doi:10.1038/nm0105-4b
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Long-delayed report on Bhopal disaster offers little new information p5
T. V. Padma
doi:10.1038/nm0105-5a
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New York City foster home accused of unethical AIDS drug trials p5
Jascha Hoffman
doi:10.1038/nm0105-5b
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Traditional healers fight for recognition in South Africa's AIDS crisis p6
James Watson
doi:10.1038/nm0105-6a
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Europe's new policies bail out ailing pharma companies p6
Gunjan Sinha
doi:10.1038/nm0105-6b
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News In Brief p7
doi:10.1038/nm0105-7
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Profile: Richard Chaisson p8
Bruce Diamond
doi:10.1038/nm0105-8
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News Feature: Medicine of the masses pp9 - 10
Gunjan Sinha
doi:10.1038/nm0105-9
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| Correspondence | Top |
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Avoiding the effect of linked genes is crucial to elucidate the role of Apcs in autoimmunity pp11 - 12
Toshio Tamaoki, Hideo Tezuka, Yoshiie Okada, Sadahiro Ito, Hiroki Shimura, Mihoko Sakamoto, Toyoshi Endo, Yukio Ozaki, Shigenobu Kanba
& Shuichiro Maeda
doi:10.1038/nm0105-11
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Reply to: Avoiding the effect of linked genes is crucial to elucidate the role of Apcs in autoimmunity pp12 - 13
M.B. Pepys
doi:10.1038/nm0105-12
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Simple test for multiple sclerosis p13
Anna Maria Papini
doi:10.1038/nm0105-13
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(70K)
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| Book Reviews | Top |
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A fragile web p15
Reviewed by: Tony Barnett
doi:10.1038/nm0105-15
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Deeper than DNA p16
Reviewed by: Morris W Foster
doi:10.1038/nm0105-16
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(74K)
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| News and Views | Top |
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Psoriasis: more than skin deep pp17 - 18
Mark R Pittelkow
doi:10.1038/nm0105-17
Abstract | Full text | PDF
(467K)
See also: Article by Sano et al. |
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Bacteria spurned by self-absorbed cells pp18 - 19
Jean-Pierre Gorvel
& Chantal de Chastellier
doi:10.1038/nm0105-18
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(173K)
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Inflammation and cancer: the long reach of Ras pp20 - 21
Michael Karin
doi:10.1038/nm0105-20
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Inflammation and migration p21
Charlotte Schubert
doi:10.1038/nm0105-21
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B-cell lymphoma: suppressing a tumor suppressor p22
Alexander Dent
doi:10.1038/nm0105-22
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(147K)
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Clock reset for alcoholism pp23 - 24
Vadim Yuferov, Gavin Bart
& Mary Jeanne Kreek
doi:10.1038/nm0105-23
Abstract | Full text | PDF
(352K)
See also: Article by Spanagel et al. |
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Gynecologic diseases get their genes pp24 - 26
Martin M Matzuk
doi:10.1038/nm0105-24
Abstract | Full text | PDF
(207K)
See also: News and Views by Matzuk |
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Autoimmunity and apoptosis: refusing to go quietly pp26 - 27
Donna L Bratton
& Peter M Henson
doi:10.1038/nm0105-26
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(126K)
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Research Highlights p28
doi:10.1038/nm0105-28
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(122K)
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| Brief Communications | Top |
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Heart transplantation in baboons using  1,3-galactosyltransferase gene-knockout pigs as donors: initial experience pp29 - 31
Kenji Kuwaki, Yau-Lin Tseng, Frank J M F Dor, Akira Shimizu, Stuart L Houser, Todd M Sanderson, Courtney J Lancos, Derek D Prabharasuth, Jane Cheng, Kathleen Moran, Yosuke Hisashi, Nicolas Mueller, Kazuhiko Yamada, Julia L Greenstein, Robert J Hawley, Clive Patience, Michel Awwad, Jay A Fishman, Simon C Robson, Henk-Jan Schuurman, David H Sachs
& David K C Cooper
Published online: 26 December 2004 | doi:10.1038/nm1171
Abstract | Full text | PDF
(467K)
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Marked prolongation of porcine renal xenograft survival in baboons through the use of 1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue pp32 - 34
Kazuhiko Yamada, Koji Yazawa, Akira Shimizu, Takehiro Iwanaga, Yosuke Hisashi, Matthew Nuhn, Patricia O'Malley, Shuji Nobori, Parsia A Vagefi, Clive Patience, Jay Fishman, David K C Cooper, Robert J Hawley, Julia Greenstein, Henk-Jan Schuurman, Michel Awwad, Megan Sykes
& David H Sachs
Published online: 26 December 2004 | doi:10.1038/nm1172
Abstract | Full text | PDF
(253K)
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| Articles | Top |
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The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption pp35 - 42
Rainer Spanagel, Gurudutt Pendyala, Carolina Abarca, Tarek Zghoul, Carles Sanchis-Segura, Maria Chiara Magnone, Jesús Lascorz, Martin Depner, David Holzberg, Michael Soyka, Stefan Schreiber, Fumihiko Matsuda, Mark Lathrop, Gunter Schumann
& Urs Albrecht
Published online: 19 December 2004 | doi:10.1038/nm1163
Abstract | Full text | PDF
(709K)
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See also: News and Views by Yuferov et al. |
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Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model pp43 - 49
Shigetoshi Sano, Keith Syson Chan, Steve Carbajal, John Clifford, Mary Peavey, Kaoru Kiguchi, Satoshi Itami, Brian J Nickoloff
& John DiGiovanni
Published online: 12 December 2004 | doi:10.1038/nm1162
Abstract | Full text | PDF
(1,098K)
| Supplementary Information
See also: News and Views by Pittelkow |
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Inhibition of respiratory viruses by nasally administered siRNA pp50 - 55
Vira Bitko, Alla Musiyenko, Olena Shulyayeva
& Sailen Barik
Published online: 26 December 2004 | doi:10.1038/nm1164
Abstract | Full text | PDF
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Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene pp56 - 62
Weidong Zhang, Hong Yang, Xiaoyuan Kong, Subhra Mohapatra, Homero San Juan-Vergara, Gary Hellermann, Sumita Behera, Rajeswari Singam, Richard F Lockey
& Shyam S Mohapatra
Published online: 26 December 2004 | doi:10.1038/nm1174
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(558K)
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Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer pp63 - 70
Daniela M Dinulescu, Tan A Ince, Bradley J Quade, Sarah A Shafer, Denise Crowley
& Tyler Jacks
Published online: 26 December 2004 | doi:10.1038/nm1173
Abstract | Full text | PDF
(1,901K)
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See also: News and Views by Matzuk |
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| Letters | Top |
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Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway pp71 - 76
Alessandra Insinga, Silvia Monestiroli, Simona Ronzoni, Vania Gelmetti, Francesco Marchesi, Andrea Viale, Lucia Altucci, Clara Nervi, Saverio Minucci
& Pier Giuseppe Pelicci
Published online: 26 December 2004 | doi:10.1038/nm1160
Abstract | Full text | PDF
(768K)
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Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells pp77 - 84
Angela Nebbioso, Nicole Clarke, Emilie Voltz, Emmanuelle Germain, Concetta Ambrosino, Paola Bontempo, Rosana Alvarez, Ettore M Schiavone, Felicetto Ferrara, Francesco Bresciani, Alessandro Weisz, Angel R de Lera, Hinrich Gronemeyer
& Lucia Altucci
Published online: 26 December 2004 | doi:10.1038/nm1161
Abstract | Full text | PDF
(594K)
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Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry pp85 - 89
Micah T McClain, Latisha D Heinlen, Gregory J Dennis, Jon Roebuck, John B Harley
& Judith A James
Published online: 26 December 2004 | doi:10.1038/nm1167
Abstract | Full text | PDF
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Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 pp90 - 94
Akira Hirasawa, Keiko Tsumaya, Takeo Awaji, Susumu Katsuma, Tetsuya Adachi, Masateru Yamada, Yukihiko Sugimoto, Shunichi Miyazaki
& Gozoh Tsujimoto
Published online: 26 December 2004 | doi:10.1038/nm1168
Abstract | Full text | PDF
(567K)
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Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 pp90 - 94
Akira Hirasawa, Keiko Tsumaya, Takeo Awaji, Susumu Katsuma, Tetsuya Adachi, Masateru Yamada, Yukihiko Sugimoto, Shunichi Miyazaki
& Gozoh Tsujimoto
Published online: 26 December 2004 | doi:10.1038/nm1168
Abstract | Full text | PDF
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| Technical Report | Top |
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Tissue-print and print-phoresis as platform technologies for the molecular analysis of human surgical specimens: mapping tumor invasion of the prostate capsule pp95 - 101
Sandra M Gaston, Marc A Soares, M Minhaj Siddiqui, Dang Vu, Jung M Lee, Dana L Goldner, Mark J Brice, Jennifer C Shih, Melissa P Upton, George Perides, Jovanna Baptista, Philip T Lavin, B Nicolas Bloch, Elizabeth M Genega, Mark A Rubin
& Robert E Lenkinski
Published online: 26 December 2004 | doi:10.1038/nm1169
Abstract | Full text | PDF
(712K)
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| Erratum | Top |
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Erratum: AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not maintenance of hematopoietic stem cells in adult hematopoiesis p102
M Ichikawa, T Asai, T Saito, G Yamamoto, S Seo, I Yamazaki, T Yamagata, K Mitani, S Chiba, H Hirai, S Ogawa
& M Kurokawa
doi:10.1038/nm0105-102a
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| Corrigendum | Top |
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Corrigendum: Historical Research Highlights: KSHV and cancer p102
doi:10.1038/nm0105-102b
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