Access
To read this story in full you will need to login or make a payment (see right).
Article
Nature Medicine 11, 43 - 49 (2004)
Published online: 12 December 2004 | doi:10.1038/nm1162
Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
Shigetoshi Sano1,5,6, Keith Syson Chan1,5, Steve Carbajal1, John Clifford2, Mary Peavey1, Kaoru Kiguchi1, Satoshi Itami3, Brian J Nickoloff4 & John DiGiovanni1
Abstract
Here we report that epidermal keratinocytes in psoriatic lesions are characterized by activated Stat3. Transgenic mice with keratinocytes expressing a constitutively active Stat3 (K5.Stat3C mice) develop a skin phenotype either spontaneously, or in response to wounding, that closely resembles psoriasis. Keratinocytes from K5.Stat3C mice show upregulation of several molecules linked to the pathogenesis of psoriasis. In addition, the development of psoriatic lesions in K5.Stat3C mice requires cooperation between Stat3 activation in keratinocytes and activated T cells. Finally, abrogation of Stat3 function by a decoy oligonucleotide inhibits the onset and reverses established psoriatic lesions in K5.Stat3C mice. Thus, targeting Stat3 may be potentially therapeutic in the treatment of psoriasis.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Lessons Learned from Psoriatic Plaques Concerning Mechanisms of Tissue Repair, Remodeling, and InflammationJournal of Investigative Dermatology Symposium Proceedings Original Article
The Rate of Formation of Corneocyte Layers after Stripping the Noninvolved Psoriatic Skin and its Relation to Parakeratosis and Epidermal Enzyme LevelsJournal of Investigative Dermatology Original Article
Anti-CD11a Ameliorates Disease in the Human Psoriatic Skin?SCID Mouse Transplant Model: Comparison of Antibody to CD11a with Cyclosporin A and Clobetasol PropionateLaboratory Investigation Article Response
See all 58 matches for Research