Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 11, 17 - 18 (2005)
doi:10.1038/nm0105-17
Psoriasis: more than skin deep
Mark R Pittelkow1
- The author is in the Departments of Dermatology and Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. e-mail: pittelkow.mark@mayo.edu
Abstract
Psoriasis develops through interactions between the skin and immune system. The cell-signaling molecule Stat3 now emerges as a bridge between the two, initiating perturbations in the epidermis and generating misguided T-cell responses (pages 43–49).
Psoriasis, an autoimmune disorder of the skin and joints, results from complex, aberrant relationships between the skin and immune system, as well as genetic makeup and factors in the environment1. A central quandry of researchers studying this disease is whether it is triggered and propogated within the skin or by the T cell.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse modelNature Medicine Article (01 Jan 2005)
Latent TGFβ1 overexpression in keratinocytes results in a severe psoriasis-like skin disorderThe EMBO Journal Article (21 Apr 2004)
Anti-CD11a Ameliorates Disease in the Human Psoriatic Skin?SCID Mouse Transplant Model: Comparison of Antibody to CD11a with Cyclosporin A and Clobetasol PropionateLaboratory Investigation Article Response
Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteinsNature Article (15 Sep 2005)
See all 5 matches for Research