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Nature Medicine  11, 90 - 94 (2004)
Published online: 26 December 2004; | doi:10.1038/nm1168

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

Akira Hirasawa, Keiko Tsumaya, Takeo Awaji, Susumu Katsuma, Tetsuya Adachi, Masateru Yamada, Yukihiko Sugimoto, Shunichi Miyazaki & Gozoh Tsujimoto
 
Figure 1 thumbnailFigure 1.
Tissue distribution and signal transduction of Gpr120.

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Long FFA−induced GLP-1 secretion and ERK activation in STC-1 cells.

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Figure 3 thumbnailFigure 3.
Gpr120, but not Gpr40, mediates FFA-induced [Ca2+]i response and GLP-1 secretion.

Full FigureFull Figure and legend (81K)		 Figure 4 thumbnailFigure 4.
Colocalization of GPR120 mRNA and GLP-1 in human colonic cells, and FFA-induced GLP-1 and insulin secretion in mice.

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