 | Figure 4
Nature Medicine
11, 90 - 94 (2004)
Published online: 26 December 2004; | doi:10.1038/nm1168
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120Akira Hirasawa, Keiko Tsumaya, Takeo Awaji, Susumu Katsuma, Tetsuya Adachi, Masateru Yamada, Yukihiko Sugimoto, Shunichi Miyazaki
& Gozoh Tsujimoto | | | | Figure 4. Colocalization of GPR120 mRNA and GLP-1 in human colonic cells, and FFA-induced GLP-1 and insulin secretion in mice.
(a) In situ hybridization for GPR120 (ISH) and immunohistochemistry with antibody to GLP-1 (IHC). (b) Real-time RT-PCR of either GLP-1-immunoreactive cells (Positive) or the GLP-1-unstained mucosa (negative). (c,d) Effects of  -linolenic acids intubation on plasma GLP-1 and insulin concentrations in portal vein and inferior vena cava of mice. (e) Effects of fatty acids intubation on plasma GLP-1 concentrations in portal vein of mouse. *
P < 0.05.**
P < 0.01. Error bars represent s.e.m.
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