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Nature Medicine  11, 43 - 49 (2004)
Published online: 12 December 2004; | doi:10.1038/nm1162

Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model

Shigetoshi Sano, Keith Syson Chan, Steve Carbajal, John Clifford, Mary Peavey, Kaoru Kiguchi, Satoshi Itami, Brian J Nickoloff & John DiGiovanni
 
Figure 1 thumbnailFigure 1.
Epidermal keratinocytes of psoriatic lesions show activated Stat3.

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 Figure 2 thumbnailFigure 2.
Psoriatic lesions in K5.Stat3C mice.

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Figure 3 thumbnailFigure 3.
Alterations associated with the psoriatic phenotype.

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 Figure 4 thumbnailFigure 4.
Involvement of T cells in generation of psoriatic phenotype.

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Figure 5 thumbnailFigure 5.
Pretreatment with Stat3 decoy DNA prevents development of psoriatic lesions in K5.Stat3C mice.

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