Nature Medicine11, 32 - 34 (2004)
Published online: 26 December 2004; | doi:10.1038/nm1172
Marked prolongation of porcine renal xenograft survival in baboons through the use of 1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
Kazuhiko Yamada1, Koji Yazawa1, Akira Shimizu1, Takehiro Iwanaga1, Yosuke Hisashi1, Matthew Nuhn1, Patricia O'Malley1, Shuji Nobori1, Parsia A Vagefi1, Clive Patience2, Jay Fishman3, David K C Cooper1, Robert J Hawley2, Julia Greenstein2, Henk-Jan Schuurman2, Michel Awwad2, Megan Sykes1
& David H Sachs1
1
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA.
2
Immerge BioTherapeutics, Cambridge, Massachusetts 02139, USA.
3
Infectious Disease Unit, Massachusetts General Hospital, Boston, Massachusetts, 02129 USA.
The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using -1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.
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1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.
