Nature Medicine
10, 982 - 986 (2004)
Published online: 29 August 2004; | doi:10.1038/nm1098
CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formationJill R Crittenden, Wolfgang Bergmeier, Yanyu Zhang, Crystal L Piffath, Yuqiong Liang, Denisa D Wagner, David E Housman
& Ann M GraybielSupplementary Fig. 1 (pdf 644K)
Aggregation assays in response to calcium ionophore A23187. Supplementary Table 1 (pdf 18K)
Clotting factor assays in CalDAG-GEFT-/- mice. Supplementary Table 2 (pdf 25K)
Blood cell counts in CalDAG-GEFT-/- mice. Supplementary Video 1 (mov 2659K)
Platelets in whole blood from CalDAG-GEFI knockout mice do not form thrombi on a collagen surface. Real-time movies of platelets perfused over a collagen plate. a, wild-type calcein-labeled platelets, and b, CalDAG-GEFI-/- calcein-labeled platelets.
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