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Letter
Nature Medicine 10, 987-992 (1 September 2004) | doi:10.1038/nm1089;
Donor APCs are required for maximal GVHD but not for GVL
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Abstract
Graft-versus-host disease (GVHD) is a major source of morbidity in allogenic stem cell transplantation. We previously showed that recipient antigen-presenting cells (APCs) are required for CD8-dependent GVHD in a mouse model across only minor histocompatibility antigens (minor H antigens).
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