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| A series of articles highlighting the major biomedical achievements of the past decade. |
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| Editorial | Top |
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Lost in clinical translation p879
doi:10.1038/nm0904-879
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(48K)
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| News | Top |
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Edible vaccines not ready for main course p881
Peter Vermij
doi:10.1038/nm0904-881
Abstract | Full text | PDF
(142K)
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High-flying patents get their wings clipped in Europe p882
David Cyranoski
doi:10.1038/nm0904-882a
Abstract | Full text | PDF
(110K)
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California dreaming about 'ill-conceived' stem cell plan p882
Kris Novak
doi:10.1038/nm0904-882b
Abstract | Full text | PDF
(110K)
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'Fast-track' drug approvals hit speed bumps in Japan p883
Douglas Sipp
doi:10.1038/nm0904-883a
Abstract | Full text | PDF
(157K)
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UK cracks down on animal-rights activists p883
Xavier Bosch
doi:10.1038/nm0904-883b
Abstract | Full text | PDF
(157K)
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Soaring drug prices send experts scrambling for a fix p884
Emily Singer
doi:10.1038/nm0904-884a
Abstract | Full text | PDF
(118K)
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NIH lab shutdown raises concerns about US prion research p884
Tinker Ready
doi:10.1038/nm0904-884b
Abstract | Full text | PDF
(118K)
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News In Brief p885
doi:10.1038/nm0904-885
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(108K)
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Profile: Malik Peiris p886
Apoorva Mandavilli
doi:10.1038/nm0904-886
Abstract | Full text | PDF
(102K)
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| Commentary | Top |
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Cancer immunotherapy: breaking the barriers to harvest the crop pp887 - 892
Drew Pardoll
& James Allison
doi:10.1038/nm0904-887
Abstract | Full text | PDF
(1,860K)
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| Book Reviews | Top |
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Laws for the 'beast machine' p893
Reviewed by: George J Annas
doi:10.1038/nm0904-893
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(103K)
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Tracing the scientific trajectory p894
Reviewed by: Charles Tanford
& Jacqueline Reynolds
doi:10.1038/nm0904-894
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(84K)
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| News and Views | Top |
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Autoimmune hypothyroidism: T cells caught in the act pp895 - 896
Sandra M McLachlan
& Basil Rapoport
doi:10.1038/nm0904-895
Abstract | Full text | PDF
(316K)
See also: Article by Quaratino et al. |
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Aneurysms: leukotrienes weaken aorta from the outside pp896 - 898
Wulf Palinski
doi:10.1038/nm0904-896
Abstract | Full text | PDF
(775K)
| Supplementary Information
See also: Article by Zhao et al. |
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Epithelial cells pay a Toll for protection pp898 - 900
Warren Strober
doi:10.1038/nm0904-898
Abstract | Full text | PDF
(841K)
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Fatal attraction: tumors beckon regulatory T cells pp900 - 901
Ethan M Shevach
doi:10.1038/nm0904-900
Abstract | Full text | PDF
(2,586K)
See also: Article by Curiel et al. |
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When good cholesterol goes bad pp902 - 903
Alan M Fogelman
doi:10.1038/nm0904-902
Abstract | Full text | PDF
(443K)
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Mutated matrix gene mars macula p903
Charlotte Schubert
doi:10.1038/nm0904-903
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(230K)
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Lung immunity: necessity is the mother of induction pp904 - 905
Max Corbett
& Jean-Pierre Kraehenbuhl
doi:10.1038/nm0904-904
Abstract | Full text | PDF
(137K)
See also: Article by Moyron-Quiroz et al. |
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Maiming mitochondria in familial ALS pp905 - 906
Valina L Dawson
doi:10.1038/nm0904-905
Abstract | Full text | PDF
(116K)
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Research highlights p907
doi:10.1038/nm0904-907
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(114K)
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| Perspective | Top |
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Cancer immunotherapy: moving beyond current vaccines pp909 - 915
Steven A Rosenberg, James C Yang
& Nicholas P Restifo
doi:10.1038/nm1100
Abstract | Full text | PDF
(118K)
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| Brief Communication | Top |
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The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer pp917 - 919
Héctor G Pálmer, María Jesús Larriba, José Miguel García, Paloma Ordóñez-Morán, Cristina Peña, Sandra Peiró, Isabel Puig, Rufo Rodríguez, Ricardo de la Fuente, Antonio Bernad, Marina Pollán, Félix Bonilla, Carlos Gamallo, Antonio García de Herreros
& Alberto Muñoz
Published online: 22 August 2004 | doi:10.1038/nm1095
Abstract | Full text | PDF
(1,142K)
| Supplementary Information |
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| Articles | Top |
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Degenerate self-reactive human T-cell receptor causes spontaneous autoimmune disease in mice pp920 - 926
Sonia Quaratino, Ester Badami, Yun Yun Pang, Istvan Bartok, Julian Dyson, Dimitris Kioussis, Marco Londei
& Luigi Maiuri
Published online: 15 August 2004 | doi:10.1038/nm1092
Abstract | Full text | PDF
(1,171K)
| Supplementary Information
See also: News and Views by McLachlan & Rapoport |
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Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity pp927 - 934
Juan E Moyron-Quiroz, Javier Rangel-Moreno, Kim Kusser, Louise Hartson, Frank Sprague, Stephen Goodrich, David L Woodland, Frances E Lund
& Troy D Randall
Published online: 15 August 2004 | doi:10.1038/nm1091
Abstract | Full text | PDF
(1,833K)
| Supplementary Information
See also: News and Views by Corbett & Kraehenbuhl |
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Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin pp935 - 941
Stéphane Temmerman, Kevin Pethe, Marcela Parra, Sylvie Alonso, Carine Rouanet, Thames Pickett, Annie Drowart, Anne-Sophie Debrie, Giovanni Delogu, Franco D Menozzi, Christian Sergheraert, Michael J Brennan, Françoise Mascart
& Camille Locht
Published online: 08 August 2004 | doi:10.1038/nm1090
Abstract | Full text | PDF
(571K)
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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival pp942 - 949
Tyler J Curiel, George Coukos, Linhua Zou, Xavier Alvarez, Pui Cheng, Peter Mottram, Melina Evdemon-Hogan, Jose R Conejo-Garcia, Lin Zhang, Matthew Burow, Yun Zhu, Shuang Wei, Ilona Kryczek, Ben Daniel, Alan Gordon, Leann Myers, Andrew Lackner, Mary L Disis, Keith L Knutson, Lieping Chen
& Weiping Zou
Published online: 22 August 2004 | doi:10.1038/nm1093
Abstract | Full text | PDF
(735K)
| Supplementary Information
See also: News and Views by Shevach |
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Tumor-infiltrating dendritic cell precursors recruited by a  -defensin contribute to vasculogenesis under the influence of Vegf-A pp950 - 958
Jose R Conejo-Garcia, Fabian Benencia, Maria-Cecilia Courreges, Eugene Kang, Alisha Mohamed-Hadley, Ronald J Buckanovich, David O Holtz, Ann Jenkins, Hana Na, Lin Zhang, Daniel S Wagner, Dionyssios Katsaros, Richard Caroll
& George Coukos
Published online: 29 August 2004 | doi:10.1038/nm1097
Abstract | Full text | PDF
(1,441K)
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Reticulon family members modulate BACE1 activity and amyloid- peptide generation pp959 - 965
Wanxia He, Yifeng Lu, Isam Qahwash, Xiang-You Hu, Ansi Chang
& Riqiang Yan
Published online: 01 August 2004 | doi:10.1038/nm1088
Abstract | Full text | PDF
(1,266K)
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The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm pp966 - 973
Lei Zhao, Michael P W Moos, Rolf Gräbner, Frédérique Pédrono, Jinjin Fan, Brigitte Kaiser, Nicole John, Sandra Schmidt, Rainer Spanbroek, Katharina Lötzer, Li Huang, Jisong Cui, Daniel J Rader, Jilly F Evans, Andreas J R Habenicht
& Colin D Funk
Published online: 22 August 2004 | doi:10.1038/nm1099
Abstract | Full text | PDF
(1,492K)
| Supplementary Information
See also: News and Views by Palinski |
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Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis pp974 - 981
Tatiana V Petrova, Terhi Karpanen, Camilla Norrmén, Russell Mellor, Tomoki Tamakoshi, David Finegold, Robert Ferrell, Dontscho Kerjaschki, Peter Mortimer, Seppo Ylä-Herttuala, Naoyuki Miura
& Kari Alitalo
Published online: 22 August 2004 | doi:10.1038/nm1094
Abstract | Full text | PDF
(1,005K)
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| Letters | Top |
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CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation pp982 - 986
Jill R Crittenden, Wolfgang Bergmeier, Yanyu Zhang, Crystal L Piffath, Yuqiong Liang, Denisa D Wagner, David E Housman
& Ann M Graybiel
Published online: 29 August 2004 | doi:10.1038/nm1098
Abstract | Full text | PDF
(494K)
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Donor APCs are required for maximal GVHD but not for GVL pp987 - 992
Catherine C Matte, Jinli Liu, James Cormier, Britt E Anderson, Ioanna Athanasiadis, Dhanpat Jain, Jennifer McNiff
& Warren D Shlomchik
Published online: 01 August 2004 | doi:10.1038/nm1089
Abstract | Full text | PDF
(559K)
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| Technical Report | Top |
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Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy pp993 - 998
Evelyn B Voura, Jyoti K Jaiswal, Hedi Mattoussi
& Sanford M Simon
Published online: 29 August 2004 | doi:10.1038/nm1096
Abstract | Full text | PDF
(516K)
| Supplementary Information |
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| Erratum | Top |
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Erratum: Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells p999
Alexandra Aicher, Christopher Heeschen, Christiane Mildner-Rihm, Carmen Urbich, Christian Ihling, Katja Technau-Ihling, Andreas M Zeiher
& Stephanie Dimmeler
doi:10.1038/nm0904-999
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(123K)
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| New on the Market | Top |
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New on the market p1001
doi:10.1038/nm0904-1001
Full text | PDF
(135K)
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