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Volume 10 Issue 9, September 2004

Mutations affecting the forkhead transcription factor FoxC2 are known to underlie lymphedema-distichiasis syndrome. On page 974 of this issue, Petrova et al. show that FoxC2 is important for lymphatic valve morphogenesis and for keeping lymphatic capillaries free of pericytes. The cover image shows abnormally patterned and enlarged lymphatic vessels in the skin of Foxc2+/−; Vegfr3+/lacZ embryos (visualized by staining for β-galactosidase).

Volume 10 Issue 9

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Editorial

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News

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Commentary

  • Successful translation of modern molecular immunology into effective cancer immunotherapy is threatened by regulatory barriers and challenges to the development of novel agents and combinatorial strategies through effective public-private partnerships. For its promise to be fully realized, both the National Cancer Institute and Food and Drug Administration must take active steps to help academic investigators and companies jointly navigate the pathways from laboratory to clinic.

    • Drew Pardoll
    • James Allison
    Commentary
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Book Review

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News & Views

  • Autoantibodies to thyroid peroxidase are the hallmark of Hashimoto thyroiditis, the most common form of thyroid autoimmunity. However, the relative contribution of antibodies and T cells to disease has been a long-standing controversy—now settled by a transgenic mouse model. Thyroid peroxidase–specific T cells, in the absence of mature B cells and antibodies, spontaneously infiltrate and destroy the thyroid gland, causing overt hypothyroidism and obesity (pages 920–926).

    • Sandra M McLachlan
    • Basil Rapoport
    News & Views

  • 5-lipoxygenase, a key enzyme in the formation of proinflammatory leukotrienes, is upregulated in the macrophages of the outer layer of the aorta and promotes aneurysm formation in mice fed a high cholesterol diet. Could this point to nonsurgical prevention of aortic aneurysms (pages 966–973)?

    • Wulf Palinski
    News & Views

  • Ligands from commensal microflora can stimulate Toll-like receptors on the surface of intestinal epithelial cells. Work in mice now assigns a surprising role to such signals: cell survival and repair during inflammation.

    • Warren Strober
    News & Views

  • Tumor tissue and ascites from patients with ovarian cancer contain high levels of cells with all the hallmarks of regulatory T cells. These cells migrate into the tumor microenvironment in a process mediated by the chemokine CCL22, and are capable of suppressing antitumor responses (pages 942–949).

    • Ethan M Shevach
    News & Views

  • High density lipoprotein (HDL) is often called the 'good cholesterol.' Products of an inflammatory enzyme, myeloperoxidase, are now shown to selectively target the main protein in HDL, apolipoprotein A-I. This turns the 'good cholesterol' bad.

    • Alan M Fogelman
    News & Views

  • Lymphoid structures, complete with B cell follicles, germinal centers, and T cell zones, form in the lung in response to influenza infection. This finding casts new light on respiratory immunity, showing that it is more self-contained than previously thought (927–934).

    • Max Corbett
    • Jean-Pierre Kraehenbuhl
    News & Views

  • A population of neurons in patients with familial amyotrophic lateral sclerosis have multiple abnormalities, including protein aggregation and mitochondrial dysfunction. Two studies now reveal interactions between these two defects.

    • Valina L Dawson
    News & Views
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Perspective

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Brief Communication

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Article

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Letter

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Technical Report

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Erratum

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