Fatal attraction: tumors beckon regulatory T cells
Ethan M Shevach
Ethan M Shevach is at the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N315, Bethesda, Maryland 20892, USA. eshevach@niaid.nih.gov
Tumor tissue and ascites from patients with ovarian cancer contain high levels of cells with all the hallmarks of regulatory T cells. These cells migrate into the tumor microenvironment in a process mediated by the chemokine CCL22, and are capable of suppressing antitumor responses (pages 942−949).
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