Aneurysms: leukotrienes weaken aorta from the outside
Wulf Palinski
Wulf Palinski is in the Department of Medicine, University of California, San Diego, La Jolla, California 92093-0682, USA. wpalinski@ucsd.edu
5-lipoxygenase, a key enzyme in the formation of proinflammatory leukotrienes, is upregulated in the macrophages of the outer layer of the aorta and promotes aneurysm formation in mice fed a high cholesterol diet. Could this point to nonsurgical prevention of aortic aneurysms (pages 966−973)?
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