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Brief Communication
Nature Medicine 10, 813 - 815 (2004)
Published online: 4 July 2004 | doi:10.1038/nm1078
Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
Lu Chen1, Pedram Hamrah1, Claus Cursiefen1, Qiang Zhang1, Bronislaw Pytowski2, J Wayne Streilein1 & M Reza Dana1
Abstract
There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.
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