Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 10, 778 - 780 (2004)
doi:10.1038/nm0804-778
Redistricting the retroviral restriction factors
Warner C Greene1
- Warner C. Greene is at the Gladstone Institute of Virology and Immunology, and University of California, San Francisco, San Francisco, California 94141, USA e-mail: wgreene@gladstone.ucsf.edu
Abstract
The cytoplasmic protein TRIM5
blocks the growth of HIV in rhesus monkey cells. Three studies now show that TRIM5 is an even more broadly active inhibitor. It impairs the growth of highly divergent retroviruses in human and other primate cells and fully accounts for many previously described antiretroviral activities.
The recent discovery by Stemlau et al. that rhesus TRIM5 blocks the early growth of HIV within rhesus monkey cells1 has spread with tsunami-like force through the virology community. This viral restriction factor acts within cells, inhibiting HIV replication after entry but before reverse transcription of the viral RNA.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
HIV-1 infection: fooling the gatekeeperNature Medicine News and Views (01 Sep 2003)
Good to CUNature News and Views (03 Jul 2003)
RESEARCH
Tissue-specific restriction of cyclophilin A-independent HIV-1- and SIV-derived lentiviral vectorsGene Therapy Original Article
Active site remodeling switches HIV specificity of antiretroviral TRIMCypNature Structural & Molecular Biology Article (01 Oct 2009)
See all 9 matches for Research