Nature Medicine10, 813 - 815 (2004)
Published online: 4 July 2004; | doi:10.1038/nm1078
Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
Lu Chen1, Pedram Hamrah1, Claus Cursiefen1, Qiang Zhang1, Bronislaw Pytowski2, J Wayne Streilein1
& M Reza Dana1
1
Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA.
2
ImClone Systems, 180 Varick Street, New York, New York, USA.
There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
