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Nature Medicine  10, 780 - 781 (2004)
doi:10.1038/nm0804-780

Staphylococcal protein A inflames the lungs

Birgitta Henriques Normark, Staffan Normark & Anna Norrby-Teglund

The authors are at the Swedish Institute for Infectious Disease Control, Solna, the Microbiology and Tumor Biology Center, and the Centre for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden. birgitta.henriques@smi.ki.se

Staphylococcal pneumonia is associated with a huge influx of inflammatory cells into the lungs. A major trigger for this event is now revealed. Protein A, a bacterial surface protein, binds the receptor for TNFalpha, a prominent activator of the innate immune system (pages 842−848).

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ISSN: 1078-8956
EISSN: 1546-170X
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