Warner C. Greene is at the Gladstone Institute of Virology and Immunology, and University of California, San Francisco, San Francisco, California 94141, USA wgreene@gladstone.ucsf.edu
The cytoplasmic protein TRIM5 blocks the growth of HIV in rhesus monkey cells. Three studies now show that TRIM5 is an even more broadly active inhibitor. It impairs the growth of highly divergent retroviruses in human and other primate cells and fully accounts for many previously described antiretroviral activities.
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blocks the growth of HIV in rhesus monkey cells. Three studies now show that TRIM5
