Urgently needed: a filter for the HIV-1 vaccine pipeline
John P Moore1
& Dennis R Burton2
1
John P. Moore is in the Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA. jpm2003@med.cornell.edu
2
Dennis R. Burton is in the Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA. burton@scripps.edu
Research groups worldwide are trying to make immunogens intended to elicit neutralizing antibody responses as part of a prophylactic vaccine to counter the spread of HIV-1. The relative merits of different designs can only be gauged properly through comparative studies, and particularly by evaluating human or animal antisera under identical, or comparable, conditions. Hence there is a need for assay standardization and for the creation of a centralized testing facility that could distribute consensus protocols and reagents.
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