Nature Reviews Neuroscience 5, S34–S41 (2004) Advances in the early detection of Alzheimer's disease The combination of an aging population and the promise, possibly in the near future, of disease-modifying therapies have made the characterization of the early stages of Alzheimer's disease (AD) a topic of major research interest. In this article we review recent progress in our understanding of the evolution of early AD with particular reference to the symptomatic pre-dementia stage designated 'mild cognitive impairment', emphasizing work on the early cognitive profile and associated neuroimaging studies.
Peter J Nestor1, Philip Scheltens2
& John R Hodges1, 3
1 University Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK. 2 Department of Neurology/Alzheimer Center, VU Medisch Centrum, PO Box 7057, 1007 MB Amsterdam, The Netherlands. 3 MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK.
Correspondence should be addressed to John R Hodges john.hodges@mrc-cbu.cam.ac.uk Published online: 1 July 2004
doi:10.1038/nrn1433 |
