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Nature Medicine 10, 582 - 583 (2004)
doi:10.1038/nm0604-582
The two-timing thyroid
Stephen B Liggett1
- Stephen B. Liggett is at the University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0564, USA. e-mail: stephen.liggett@uc.edu
Abstract
Thyroid hormone regulates cellular energetics in multiple organs and sets the metabolic rate of the body. The hormone action takes days to weeks, working by altering gene transcription. Now its ability to also function over the short term is coming to light (pages 638–642).
Thyroid hormone acts by binding to nuclear receptors to regulate transcription, thereby controlling multiple homeostatic processes, such as metabolic, central nervous system and hemodynamic function. Treatment of hypothyroidism requires weeks of hormone administration to normalize such functions, consistent with this transcriptional mechanism.
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