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Brief Communication
Nature Medicine 10, 484 - 486 (2004)
Published online: 18 April 2004 | doi:10.1038/nm1042
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
Davide Ruggero1,2,4, Lorenzo Montanaro1,2, Li Ma1,2, Wei Xu1,2, Paola Londei3, Carlos Cordon-Cardo2 & Pier Paolo Pandolfi1,2
Abstract
The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.
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