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News and Views
Nature Medicine 10, 454 - 455 (2004)
doi:10.1038/nm0504-454
Fat hormones pull their weight in the CNS
Randy J Seeley1, David A D'Alessio1 & Stephen C Woods1
- Randy J. Seeley, David A. D'Alessio and Stephen C. Woods are in the Departments of Psychiatry and Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA. e-mail: seeleyrj@ucmail.uc.edu
Abstract
Fat cells secrete the hormone adiponectin, which regulates glucose metabolism through actions on peripheral tissues. It is now apparent that adiponectin also acts on the brain to reduce body weight and improve glucose metabolism (pages 524–529).
Since the discovery of the adipocyte hormone leptin1 in the mid 1990s, fat has never been the same. Fat is clearly a source of numerous hormones—termed adipokines—with important biological actions on a number of tissues.
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