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Arming the osteoclast

Signaling through costimulatory receptors classically occurs in cells of the immune system. Now the distinction between immune cells and osteoclasts, bone resorbing cells, begins to blur. Osteoclasts need costimulatory signals too.

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Figure 1: Costimulatory ITAM-based signaling pathways mediate osteoclast differentiation.

Kimberly Caesar

Figure 2: Costimuation of osteoclasts.

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Baron, R. Arming the osteoclast. Nat Med 10, 458–460 (2004). https://doi.org/10.1038/nm0504-458

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