Roland Baron is in the Departments of Cell Biology and Orthopedics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA. roland.baron@yale.edu
Signaling through costimulatory receptors classically occurs in cells of the immune system. Now the distinction between immune cells and osteoclasts, bone resorbing cells, begins to blur. Osteoclasts need costimulatory signals too.
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