Raymond A. Frizzell and Joseph M. Pilewski are in the Departments of Cell Biology and Physiology and of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA. frizzell@pitt.edu or pilewskijm@msx.upmc.edu
Increasing sodium absorption by overexpressing the epithelial sodium channel in mouse airways results in mucus accumulation and inflammation, changes that occur in the lungs of individuals with cystic fibrosis. The development of lung disease in these mice should provide insights into a disease that has long been lacking an animal model (pages 487−493).
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