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Nature Medicine 10, 345 - 347 (2004)
doi:10.1038/nm0404-345
Putting the heat on ALS
Susanna C Benn1 & Robert H Brown Jr1
- Susanna Benn and Robert H. Brown, Jr. are in the Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. e-mail: sbenn@partners.org or e-mail: rhbrown@partners.org
Abstract
An enhancer of the heat shock response alleviates symptoms of neurodegeneration and prolongs lifespan in a mouse model of amyotrophic lateral sclerosis—even when administered after onset (pages 402–405).
In patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig disease, degeneration of motor neurons causes progressive muscular weakness, atrophy and paralysis. Respiratory failure inexorably leads to death, typically within four or five years.
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